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KMID : 1143420200130181231
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Public Health Weekly Report
2020 Volume.13 No. 18 p.1231 ~ p.1246
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Diagnosis, Treatment and Outcomes of Latent Tuberculosis in the Household Contact Investigation Programme
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Park Yong-Joon
Kim Young-Man
Shim Ji-Ae
Han Sun-Mi
Park Shin-Young
Kim Ji-Eun
Park Young-Joon
Choi Jae-Chol
Jung Sun-Young
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Abstract
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This study was conducted to check the risk of tuberculosis caused by family contact check-ups and treatment for latent
tuberculosis infection, and to provide a basis for management and policy utilization of the linked and analyzed database.
This study aimed to confirm the feasibility and effectiveness of an analysis that links latent tuberculosis infection survey
data for tuberculosis patients’ family contacts with tuberculosis reported data from the National Health Insurance
Corporation (NHI), and aimed to determine tuberculosis according to epidemiological characteristics and treatment of family contacts. Preventive effects were analyzed.
This study used a linked database between 1) household contact investigation database in KCDC between 2015 and 2018, 2) TB registry database in the Korea Centers for Disease Prevention and Control (KCDC) for household contacts and index TB cases between 2015 and 2018, and 3) NHI database for household contacts between 2014 and 2018.
In the multivariable Cox proportional hazard model, non-participation in the household contact investigation (Hazard ratio
[HR], 1.93), no treatment in LTBI (HR, 2.11), and non-completion of LTBI treatment (HR, 1.48) showed increased risk of
active TB infection, whereas completion of LTBI treatment (HR, 0.32), diagnosed as no LTBI with 1-step test (HR, 0.38) or
2-step test (HR, 0.12) showed significantly decreased risk of active TB infection, compared with no test for LTBI. In addition, we found that the incidence of TB was 6.11 times higher than those who treated LTBI when contact investigation was not performed.
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KEYWORD
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Latent tuberculosis infection (LTBI), Household contacts investigation, Treatment of LTBI
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